Reason SL, Westman EC, Godfrey R and Maguire E
Journal of Rare Disorders: Diagnosis & Therapy ISSN 2380-7245, 2017, Vol. 3 No. 1: 1
We report the novel experience of three patients with McArdle disease that have adopted a Low-Carbohydrate Ketogenic Diet (LCKD) to manage their exercise intolerance. In each case, a distinct improvement in activity and exercise tolerance was found. Plasma Creatine Kinase (CK) was significantly lowered in all three cases, with two patients exhibiting values within normal range. Overall, each patient described an improved quality of life.
Conclusion: A carbohydrate-restricted diet may provide patients with McArdle disease with a consistent energy substrate for working muscles, thereby reducing the risk of muscle damage and threat of renal failure. Further research on the use of a LCKD in McArdle disease is warranted.