The objective of the review was to systematically assess the evidence for physical training to improve exercise capacity and function in daily life in people who have McArdle Disease. The authors are Dr Ros Quinlivan (London, UK), Dr John Vissing (Denmark), Dr David Hilton-Jones (Oxford, UK), and Dr John Buckley (Chester, UK). Whilst anecdotally we know that in clinical situations McArdle people can improve greatly through regular aerobic exercise, the review found that there was not yet sufficiently robust scientific evidence.
The key finding was that further studies would be safe to conduct:
“Implications for practice - The results of small numbers of subjects in three non-randomlsed studies suggest that aerobic training is safe for people with McArdle disease; however, there is no evidence from randomised controlled trials for therapeutic benefit of aerobic exercise.
Implications for research - The proof of principle studies described in the discussion of this review suggest that it would be worthwhile to undertake randomised controlled trials of aerobic training and that such studies would be safe to perform.”